Is it possible to detect if a specific item has been destroyed?

So I was thinking about first how can an item be destroyed? Inside GUI? It cant. You have to drop it out. So if it disappears after dropped out you could check if its at any player's inventory but I have no idea how to do it and I'm 99% sure there is a better solution. I would also like to know if its possible to print a text containing a variable. Lets say: playerHead .. " has died permanently. ( Head Destroyed )"