Trigger Commands when leaving spawn

I wanted to run some commands as son as any player leaves a specific area (5x5 at 0, 55, 0) for the first time. So it should only trigger once. How can I achive that? I thought about using an advancement that when it triggers removes itself so no one can trigger it again, but I could not get this to work at all. (I have just basic knowledge about how datapacks work.) (1.21)